I heard a podcast from EASI that raved about the functionality of ToggleMOUSE for limited mobility uses. It is full of features that increase productivity all in one utility for $19.95. A couple features I liked were screen wrap where you can move the pointer off the screen at one side of the screen and come out at the other side. That helps keep the pointer from getting lost on the side of the screen. There is also a feature to make the click wheel do a left-double click with one push. There is a free evaluation version on the site. They other utilities too that might be worth checking on.Feature List
AutoMouse: Record and playback mouse and keyboard actions.
Button Functions: Assign handy functions to unused buttons and keystrokes.
EconoClick: Saves a lot of needless clicks and mouse movements.
QuickPoint: Automatically finds the default button, saves mouse movement.
QuickScroll: Enhanced scrolling options for total control.
ScreenWrap: Lets the point wrap around the edges of the screen.
PopDesk: A popup menu gives quick access to desktop items.
Cursors: Hundreds of cursors to choose from!
Keyboard Mouse: Point and click even if no mouse is attached.
Clear Type: Hides the mouse pointer while you type.
ActiMouse: Brings apps to the front when you move the mouse over them.
Blinking: Makes it easy to find the mouse pointer after it is inactive for while.
Center Cursor: Moves the mouse pointer to the center of the screen at the touch of a key.
Presto Saver: Launch your screen saver instantly.
Dynamics: Control over mouse speed and other dynamics.
Wheel Support: Enhanced mouse wheel features.